Case Study: 
Comprehensive Fragment library (CFL)

  • The next-generation 3-D fragment library
  • Designed using our team’s deep medicinal chemistry expertise to meet very strict property criteria
  • Diverse collection of rigid, low molecular weight fragments designed from first principles
  • Novel starting points with underexplored 3-D shapes for FBLD 
  • Enables access to ~ 3 million high value fragments with less than 19 heavy atoms
  • Fragment evolution cycles facilitated by searching BioBlocks’ proprietary Syntheverse™ platform enables the rapid identification of a set of diverse but closely related analogs