Chemistry Services

Lead Optimization

BioBlocks applies the best possible medicinal chemistry to reach client’s lead discovery and lead optimization goals. Our customers rely on us to bring an insightful collaborative approach to evaluating their initial hits or optimizing their early leads. BioBlocks’ chemists work with customers to ensure a robust interface with their lead optimization cycles. We are experienced in applying customers’ SAR and biological testing data to rapidly identify analoging and alternative lead strategies.

The diverse medicinal chemistry expertise of our management team spans most major therapeutic areas and numerous disease-relevant targets and mechanisms. Our medicinal chemists have developed multiple pre-clinical drug candidates from early leads in a wide variety of therapeutic areas. This track record enables us to be an effective partner in lead optimization.  

Experience has shown us that our fast cycle time and low-throughput parallel optimization will accelerate lead identification, circumvent roadblocks and reduce project risk.

BioBlocks’ Flex-FTE (Full Time Equivalent) model guarantees that our customer has the chemistry capacity available to successfully overcome the fluctuating demands of projects while meeting project goals, budgets and deadlines. We use an inclusive, cost effective pricing model that includes project management, consulting on strategy of lead discovery and optimization, integrated chemical information services, compound purification and analysis, patent support, chemical sourcing and shipping between BioBlocks and the client or between BioBlocks and the client’s CRO. BioBlocks offers highly competitive FTE rates for projects requiring four to six FTEs for six months or longer.

BioBlocks utilizes a client focused informatics platform to facilitate effective, secure and flexible synergistic collaboration, interactions, data presentations, productivity and program efficiency.

BioBlocks uses secure communications methods and has established procedures to ensure that all confidential information is safeguarded at our San Diego headquarters. We apply standardized master service agreements and work orders routinely with our customers to reduce their administrative burden. In addition, IP related to lead optimization compounds resides with the client.

Our face-to-face or real-time research discussions avoid logistical and organizational issues that a company may face with other chemistry research providers.

For further information, contact Business Development at 858-558-5900.

Custom Synthesis

At BioBlocks’ facilities, highly skilled chemists routinely carry out syntheses of complex intermediates and final products. There is a wide range of chemical transformations in a broad variety of compound classes in their repertoire. Synthesis capabilities span from small-scale through kilo quantities, covering requirements for the entire spectrum of drug discovery and development. We offer our process development capabilities to further the goals of our partners’ preclinical projects.  Our chemists have access to state-of-the-art research and analytical equipment, and cheminformatics tools to ensure that solutions are found for each challenge.

BioBlocks’ customers appreciate the contribution we make to solve their chemical synthesis challenges. The BioBlocks team develops and adapts practical synthetic strategies while working closely with customers to ensure that project goals are achieved within time and budget. Our cost-efficient synthetic services are matched with seamless logistics and fluent reporting by our senior chemistry team in San Diego.

Custom synthesis projects are quoted within 48 hours.  BioBlocks offers both fee-for-service and FTE-based pricing in its quotations.  Our standardized confidentiality and master service agreements are used routinely with our customers to reduce their administrative burden.

BioBlocks’ process development chemists specialize in the design and optimization of synthetic routes for gram to multi-kilo quantities of compounds suitable for the transfer of laboratory procedures into the pilot plant.  We aim to develop scalable, safe and economical solutions.

Research and process chemists are co-located, contributing to a smooth hand-over in the development process.

For further information, write us at


BioBlocks – TargetEx Partnership

Recognizing the need for integrated drug discovery services, BioBlocks and TargetEx have joined forces and are now offering services that begin with target identification and deliver advanced proprietary lead compounds. Learn more...